Treatment of chronic osteomyelitis with multi-dose oritavancin: a case series and literature review

Osteomyelitis occurs when microorganisms gain access to bone through contiguous dissemination, hematogenous seeding, or direct inoculation, leading to inflammatory changes and bone necrosis, hallmarks of the disease [1,2]. Compared to acute, chronic osteomyelitis is characterized by sinus tract and sequestrum development with vague symptoms. Although it was among the first infectious processes recorded, chronic osteomyelitis remains one of the most difficult to diagnose relying on a combination of clinical suspicion, laboratory, radiographic, and microbiologic findings.
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Source Type: research