The impact of statins in combination with androgen deprivation therapyin patients with advanced prostate cancer: A large observational study

Statins are one of the most commonly prescribed medications for hypercholesterolemia worldwide, with 1 in 4 Americans over 45 taking a daily statin [1]. Statins lower cholesterol levels by inhibiting the 3-hydroxy-3-methylglutaryl-coenzyme A enzyme at the rate limiting step in the mevalonate pathway of cholesterol synthesis [2]. Recent research has focused on the antineoplastic role of statins through their impact on cell proliferation, inflammation, membrane organization, and steroidogenesis [3].
Source: Urologic Oncology: Seminars and Original Investigations - Category: Urology & Nephrology Authors: Tags: Clinical-Prostate cancer Source Type: research