The impact of statins in combination with androgen deprivation therapyin patients with advanced prostate cancer: A large observational study
Statins are one of the most commonly prescribed medications for hypercholesterolemia worldwide, with 1 in 4 Americans over 45 taking a daily statin [1]. Statins lower cholesterol levels by inhibiting the 3-hydroxy-3-methylglutaryl-coenzyme A enzyme at the rate limiting step in the mevalonate pathway of cholesterol synthesis [2]. Recent research has focused on the antineoplastic role of statins through their impact on cell proliferation, inflammation, membrane organization, and steroidogenesis [3].
Source: Urologic Oncology: Seminars and Original Investigations - Category: Urology & Nephrology Authors: India Anderson-Carter, Natasza Posielski, Jinn-ing Liou, Tariq A. Khemees, Tracy M. Downs, E. Jason Abel, David F. Jarrard, Kyle A. Richards Tags: Clinical-Prostate cancer Source Type: research
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