Validation of hepatobiliary transport PET imaging in liver function assessment: Evaluation of 3 β-[18F]FCA in mouse models of liver disease

Recently, our research group reported on the development of 3 β-[18F]Fluorocholic acid (3β-[18F]FCA), a 18F labeled bile acid to detect drug interference with the bile acid transporters (drug-induced cholestasis). It was hypothesized that 3β-[18F]FCA could also be used as a non-invasive tool to monitor (regional) liver function in vivo in different liver di seases through altered expression of bile acid transporters.

Source: Nuclear Medicine and Biology - December 7, 2018 Category: Nuclear Medicine Authors: Stef De Lombaerde, Lindsey Devisscher, Jeroen Verhoeven, Sara Neyt, Hans Van Vlierberghe, Christian Vanhove, Filip De Vos Source Type: research