MicroRNA-423 –5p inhibits the progression of trophoblast cells via targeting IGF2BP1

Preeclampsia (PE) is one of the leading causes of maternal and fetal mortality globally. The imbalance of trophoblast homeostasis is closely linked with the pathogenesis of PE. MicroRNA-423 –5p (miR-423–5p) has been reported to be abnormally expressed in placenta and blood plasma of pregnant women with PE. In the present study, miR-423–5p expression in blood plasma of pregnant women with PE and healthy pregnant women was detected. Also, the roles and molecular mechanisms of miR-4 23–5p in the development of trophoblast cells were further investigated.

Source: Placenta - December 7, 2018 Category: Reproduction Medicine Authors: Li Guo, Yu Liu, Ying Guo, Yongkang Yang, Biliang Chen Source Type: research