Magnetic and CD44 Receptor Dual Targeting Redox-Responsive Polymeric Micelle for Precise Delivery of Gambogic Acid to Triple-Negative Breast Cancer

In conclusion, the tumor magnetic and CD44 receptor dual targeting redox-responsive multifunctional magnetic polymeric micelle (mPEG-HA/CSO-SS-Hex/Fe3O4/GA) has the potential to be an effective carrier in targeted drug delivery for the TNBC chemotherapy.Graphical abstractScheme of mPEG-HA/CSO-SS-Hex/Fe3O4/GA micelle preparation and magnetism-enhanced EPR in vivo and in vitro trafficking pathway of the polymeric micelles. The intracellular trafficking pathway includes receptor-meditated cellular internalization and redox-responsive triggered micelle disassembly and drug release.
Source: Asian Journal of Pharmaceutical Sciences - Category: Drugs & Pharmacology Source Type: research