The role of sphingolipids in acute kidney injury

Publication date: December 2018Source: Advances in Biological Regulation, Volume 70Author(s): Tess V. Dupre, Leah J. SiskindAbstractAcute kidney injury (AKI) is most simply defined as the rapid loss of kidney function in a matter of hours to days. AKI can manifest in a number of ways including pre-renal, post-renal, or intrinsic AKI. During acute kidney injury, multiple pathogenic processes are activated including inflammation, cell death, and the generation of reactive oxygen species, just to name a few. Sphingolipids are known to play a role in a number of the pathogenic pathways involved in the pathogenesis of many types of AKI, which suggests a role for sphingolipids in AKI. This short review will discuss the evidence for a role for sphingolipids in AKI.
Source: Advances in Biological Regulation - Category: Biology Source Type: research