TLR8: No gain, no pain

TLRs have been well characterized in the context of immunity, although TLR8 is understudied due to its controversial function in mice. In this issue of JEM, the new work by Zhang et al. (https://doi.org/10.1084/jem.20180800) demonstrates that TLR8 activated by miR-21 controls neuropathic pain using a non-MyD88–dependent pathway.
Source: The Journal of Experimental Medicine - Category: Internal Medicine Authors: Tags: Neuroinflammation, Innate Immunity and Inflammation, Neuroscience Insights Source Type: research