{gamma}{delta} T cells: A disappearing act with a big reveal

In this issue of JEM, Sandrock et al. (https://doi.org/10.1084/jem.20181439) compare the origin of IL-17–producing T cells (T17) with other T cell populations and demonstrate the role T17 cells play in skin pathology. Using two genetically modified mouse models, one with inducible T cell–specific labeling and the other with conditional T cell depletion, the authors find that T17 are mostly long-lived lymphocytes and that depleting T cells protects mice from psoriasis.
Source: The Journal of Experimental Medicine - Category: Internal Medicine Authors: Tags: Insights Source Type: research