Ginsenoside Rf inhibits COX-2 induction via peroxisome proliferator-activated receptor gamma in A549 cells

ConclusionsOur results demonstrate that ginsenoside Rf inhibits hypoxia induced-COX-2 expression and cellular migration, which are dependent on PPARγ activation. These results suggest that ginsenoside Rf has an anti-inflammatory effect under hypoxic conditions. Moreover, docking analysis of ginsenoside Rf into the active site of PPARγ suggests that the compound binds to PPARγ in a position similar to that of known agonists.
Source: Journal of Ginseng Research - Category: Complementary Medicine Source Type: research