Temporal dynamics of cortisol-associated changes in mRNA expression of glucocorticoid responsive genes FKBP5, GILZ, SDPR, PER1, PER2 and PER3in healthy humans

The glucocorticoid cortisol, regulated by the hypothalamus-pituitary-adrenal (HPA) axis, plays an essential role in both stress-related and baseline homeostasis. In peripheral tissues, it exerts its function mainly through binding to the glucocorticoid receptor (GR), encoded by NR3C1. The GR is a ligand-activated transcription factor predominantly located in the cytoplasm in a multiprotein complex consisting of chaperones and co-chaperones (Wochnik et al., 2005). Activation of the GR leads to up- and down-regulation of target gene expression, both through direct interaction between activated GR dimers and glucocorticoid responsive elements (GREs) in gene regulatory regions, and indirectly through interaction with other transcription factors.

Source: Psychoneuroendocrinology - November 30, 2018 Category: Psychiatry Authors: T ürkan Yurtsever, Fabian Streit, Jerome C. Foo, Slavena Trifonova, Robert Kumsta, Claude P. Muller, Jonathan D. Turner, Jobst Meyer, Andrea B. Schote Tags: Short Communication Source Type: research