miRNA-seq analysis of human vertebrae provides insight into the mechanism underlying GIOP

High-throughput sequencing (HTS) was recently applied to detect microRNA (miRNA) regulation in age-related osteoporosis. However, miRNA regulation has not been reported in glucocorticoid-induced osteoporosis (GIOP) patients and the mechanism of GIOP remains elusive. To comprehensively analyze the role of miRNA regulation in GIOP based on human vertebrae and to explore the molecular mechanism, a high-throughput sequencing strategy was employed to identify miRNAs involved in GIOP. Twenty-six patients undergoing spinal surgery were included in this study.

Source: Bone - November 29, 2018 Category: Orthopaedics Authors: Hui Ren, Xiang Yu, Gengyang Shen, Zhida Zhang, Qi Shang, Wenhua Zhao, Jinjing Huang, Peiyuan Yu, Meiqi Zhan, Yongqiang Lu, Ziyang Liang, Jingjing Tang, De Liang, Zhensong Yao, Zhidong Yang, Xiaobing Jiang Tags: Full Length Article Source Type: research