Skeletal phenotype of the neuropeptide Y knockout mouse

Neuropeptide Y (NPY) is involved in multiple processes such as behavior, energy and bone metabolism. Previous studies have relied on global NPY depletion to examine its effects on bone. However, this approach is unable to distinguish the central or local source of NPY influencing bone. Our aim was to identify which cells within the skeleton express Npy and establish a model that will enable us to differentiate effects of NPY derived from different cell types. We have generated the NPY floxed (NPYflox) mice using CRISPR technology.

Source: Neuropeptides - November 29, 2018 Category: Neuroscience Authors: Natalie K.Y. Wee, Benjamin P. Sinder, Sanja Novak, Xi Wang, Chris Stoddard, Brya G. Matthews, Ivo Kalajzic Source Type: research