Comparison of florfenicol pharmacokinetics in Exopalaemon carinicauda at different temperatures and administration routes

AbstractFlorfenicol is a broad ‐spectrum antibacterial drug.Exopalaemon carinicauda is important in the prawn aquaculture industry in China. Florfenicol pharmacokinetics inE.  carinicauda were studied at different temperatures andvia different routes of administration to provide a scientific basis for the rational use of drugs forE. carinicauda production. At water temperatures of 22  ± 0.4°C and 28 ± 0.3°C, after intramuscular (IM) injection and oral (per ora (PO)) administration of florfenicol at 10  mg/kg body weight (BW) and 30 mg/kg BW, respectively, the florfenicol concentration in the plasma, hepatopancreas, gills, muscles, and carapace ofE.  carinicauda was determined by high ‐performance liquid chromatography. After IM injection at different temperatures, the metabolism of florfenicol inE.  carinicauda conformed to a two ‐compartment open model with zero‐order absorption. After PO administration, the metabolism of florfenicol inE.  carinicauda was consistent with a two ‐compartment open model with first‐order absorption. Using an identical administration route but different water temperatures, the metabolism of florfenicol inE.  carinicauda was quite different. Overall, florfenicol was absorbed rapidly and distributed widely inE.  carinicauda, but elimination was slow and the bioavailability was not high. A low temperature and PO administration resulted in a low elimination rate.
Source: Journal of Veterinary Pharmacology and Therapeutics - Category: Veterinary Research Authors: Tags: ORIGINAL ARTICLE Source Type: research