Cutaneous manifestations of hematologic malignancies

AbstractIn recent years, dermatologic manifestations in oncohematologic patients have become more common.The aim of our study was to determine the incidence and heterogeneity of skin manifestations in patients followed at our Hematology Department.This observational monocentrical study was conducted on 60 patients. We divided the observed conditions in exanthematous, purpuric, vesicular ‐bullous, papulo‐nodular, urticarial and eczematous manifestations. Moreover, all lesions were classified according to pathogenesis, in: (1) specific skin manifestations, caused by neoplastic skin infiltration; (2) immune‐mediated manifestations, based on immunological mechanisms; (3) skin les ions due to immunodeficiency.Altogether, 73 clinical manifestations were reported. Specific manifestations (1) were detected in 15.1% of the cases, mainly with papulo ‐nodular appearance. Immune‐mediated manifestations (2) were found in 37 cases (50.7%), particularly with eczematous or exanthematous appearance, and leukemia was the malignancy most frequently reported in these patients. Eventually, lesions due to immunosuppression (3) were reported in 34.2% of the cases. They were represented by infections and cutaneous malignancies, and usually manifested with papulo‐nodular lesions.Skin lesions in oncohematologic patients are a common event. A multidisciplinary approach based on the collaboration between the hematologist and the dermatologist is crucial to achieve a proper diagnosis, and cor...
Source: Hematological Oncology - Category: Hematology Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research