CD99 expression is strongly associated with clinical outcome in children with B ‐cell precursor acute lymphoblastic leukaemia

SummaryOur study aimed to determine the expression pattern and clinical relevance of CD99 in paediatric B ‐cell precursor acute lymphoblastic leukaemia (BCP‐ALL). Our findings demonstrate that high expression levels of CD99 are mainly found in high‐risk BCP‐ALL, e.g.BCR ‐ABL1 andCRLF2Re/Hi, and that highCD99mRNA levels are strongly associated with a high frequency of relapse, high proportion of positive for minimal residual disease at day 29 and poor overall survival in paediatric cohorts, which indicate that CD99 is a potential biomarker for BCP ‐ALL.

Source: British Journal of Haematology - November 28, 2018 Category: Hematology Authors: Dongfeng Chen, Alessandro Camponeschi, Qingqing Wu, Natalija Gerasimcik, Huiqi Li, Xue Shen, Yujie Tan, Helene Sj ögren, Jessica Nordlund, Gudmar Lönnerholm, Jonas Abrahamsson, Linda Fogelstrand, Inga‐Lill Mårtensson Tags: Short Report Source Type: research