Pharmacokinetics and pharmacodynamics of 3 dosages of oestriol after continuous vaginal ring administration for 21 days in healthy, postmenopausal women

ConclusionAll formulations released sufficient amounts of oestriol to trigger the maximum local effect. However, there was no difference between formulations regarding surrogate parameters for clinical efficacy. A dose ‐dependency; however, was clearly demonstrated for FSH and LH. The product was well tolerated and safe.
Source: British Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: ORIGINAL ARTICLE Source Type: research