Allergic contact dermatitis due to chloramphenicol with prurigo nodularis ‐like spreading

Topical drugs containing chloramphenicol and clostridiopeptidase A are frequently used for the treatment of cutaneous ulcers and other necrotic lesions. Chloramphenicol is a bacteriostatic broad ‐spectrum antibiotic widely used in eye and skin ointments to treat bacterial infections and a well‐known cause of allergic contact dermatitis (ACD) (1). Clostridiopeptidase A, also called collagenase 1, is a proteolytic enzyme facilitating the tissue granulation with consequent re‐epithelizat ion; it has rarely been reported as cause of ACD (2).

Source: Contact Dermatitis - November 28, 2018 Category: Dermatology Authors: Paolo Romita, Luca Stingeni, Katharina Hansel, Grazia Ettorre, Anna Bosco, Francesca Ambrogio, Caterina Foti Tags: CONTACT POINT Source Type: research