Methodology of drug screening and target identification for new necroptosis inhibitors

Publication date: Available online 27 November 2018Source: Journal of Pharmaceutical AnalysisAuthor(s): PengChao Pan, ZhenYu Cai, ChunLin Zhuang, XiaoFei Chen, YiFeng ChaiAbstractApoptosis is considered as the only form of regulated cell death for a long time. However, a novel form of programmed cell death called necroptosis was recently reported. The process of necroptosis is regulated and plays a critical role in the occurrence and development of multiple human diseases. Thus, the study of the molecular mechanism of necroptosis and its effective inhibitors has been an attractive field for researchers. Herein, we introduce the molecular mechanism of necroptosis and focuse on the literatures about necroptosis drug screening in recent years. In addition, the identification of the critical drug targets of the necroptosis was also be discussed.
Source: Journal of Pharmaceutical Analysis - Category: Drugs & Pharmacology Source Type: research