The association between maternal methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphism and birth defects and adverse pregnancy outcomes

AbstractPublished studies indicate theMTHFR C677T and A1298C polymorphisms are associated with abnormal homocysteine levels, which may cause various pregnancy complications and birth defects. However, the results obtained from different studies have been inconsistent. Therefore, this meta ‐analysis explores the association betweenMTHFR polymorphisms and birth defects and adverse pregnancy outcomes. The Pubmed, ScienceDirect, Embase, China Biology Medicine literature databases and ClinicalTrials were searched. Analyses of public bias, meta ‐regression, subgroups, and sensitivity were used to ensure the robustness of our results.MTHFR C677T was significantly associated with recurrent pregnancy loss in developing countries (OR: 1.34, 95%CI: 1.20~1.50), but not developed countries (OR: 0.87, 95%CI: 0.68~1.11). No significant relationship was found betweenMTHFR A1298C and recurrent pregnancy loss (OR: 1.04, 95%CI: 0.93~1.18).MTHFR C677T and A1298C were not associated with pre ‐eclampsia (OR: 1.06 95%CI: 0.97~1.16 andOR: 1.16, 95%CI: 0.97~1.39 respectively), and C677T was not associated with placental abruption (OR: 1.03, 95%CI: 0.87~1.21), intrauterine growth retardation (OR: 1.02, 95%CI: 0.90~1.15) or congenital heart disease (OR: 1.05, 95%CI: 0.89~1.25).MTHFR C677T, but not A1298C, was associated with neural tube defects (OR: 1.24, 95%CI: 1.08~1.42) and Down Syndrome (OR: 1.65, 95%CI: 1.39~1.95).
Source: Prenatal Diagnosis - Category: Perinatology & Neonatology Authors: Tags: REVIEW Source Type: research