PCNA and JNK1 ‐Stat3 pathways respectively promotes and inhibits diabetes‐associated centrosome amplification by targeting at the ROCK1/14‐3‐3σ complex in human colon cancer HCT116 cells

In conclusion, our results suggest that PCNA and JNK1‐Stat3 pathways respectively promotes and feedback inhibits the centrosome amplificati on by targeting at the ROCK1/14‐3‐3σ complex, and NPM serves as an independent signal for the centrosome amplification.

Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Yu Cheng Lu, Pu Wang, Jie Wang, Ronald Ma, Shao Chin Lee Tags: ORIGINAL RESEARCH ARTICLE Source Type: research