A novel infram deletion in MSH6 gene in glioma: Conversation on MSH6 mutations in brain tumors

ConclusionPatients should be evaluated for MMR mutation before chemo and radiotherapy, and it is valuable to follow ‐up these mutations during the treatment too. In temozolomide (TMZ)‐resitance cases, it is suggested to use complementary strategies such as using HDACis and a combination of a STAT3 Inhibitor and an mTOR inhibitor, BER inhibition mechanism, and PARP‐1 inhibitor.

Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Zeinab Deris Zayeri, Maryam Tahmasebi Birgani, Javad Mohammadi Asl, Davood Kashipazha, Mohammadreza Hajjari Tags: ORIGINAL RESEARCH ARTICLE Source Type: research