Initial and crucial genetic events in intestinal ‐type gastric intramucosal neoplasia

This study revealed somatic mutational landscape and initial mutations of GINs, and we report for the first time thatTP53 mutations precede other mutations in intestinal ‐type GC. Our results also indicate that molecular subtyping based onAPC/TP53 mutations would be a high ‐priority approach for determining and predicting the malignant potential of GIN, including D/IEN.

Source: The Journal of Pathology - November 26, 2018 Category: Pathology Authors: Hirofumi Rokutan, Hiroyuki Abe, Hiromi Nakamura, Tetsuo Ushiku, Erika Arakawa, Fumie Hosoda, Shinichi Yachida, Yosuke Tsuji, Mitsuhiro Fujishiro, Kazuhiko Koike, Yasushi Totoki, Masashi Fukayama, Tatsuhiro Shibata Tags: Original Paper Source Type: research