Histopathological features of skin lesions in patients affected by non ‐ulcerated or atypical cutaneous leishmaniasis in Honduras, Central America
SummaryIn Honduras visceral leishmaniasis and non ‐ulcerated or atypical cutaneous leishmaniasis (NUCL) are caused by the speciesLeishmania (L.) infantum chagasi. NUCL is the most common clinical form in the southern regions of the country, mainly affecting the young. In view of the lack of knowledge about the pathogenesis of the disease pattern caused byL. (L) infantum chagasi in individuals affected by NUCL, the aim of the present study was to describe in detail the histopathological features of the skin lesion caused by the parasite. Biopsies from human NUCL lesions with a positive parasitological diagnosis were collected and processed using standard histological techniques. Paraffin sections stained by haematoxylin and eosin were used to examine the histopathological alterations seen in the skin. The lesions varied between 3 and 5 mm, and the majority of the patients (60%) had a single lesion. Lesions were more frequently seen in females (65%), with an average age of 33.4 years. Microscopically, the skin lesions were characterized by mononuclear inflammatory infiltrate in the dermis composed of lymphocytes, macrophages and a few plasma cells. The intensity of the infiltration varied from discrete to intense. In both cases, the parasitic infection was discrete. Granulomas were present in 60% of cases and were associated with intense inflammation. The data revealed by the histopathological alterations in the skin of in dividuals affected by NUCL suggest activation of a...
Source: International Journal of Experimental Pathology - Category: Pathology Authors: Carmen Maria Sandoval Pacheco,
Gabriela Venicia Araujo Flores,
Aurea Favero Ferreira,
Wilfredo Sosa Ochoa,
V ânia Lúcia Ribeiro da Matta,
Concepción Zúniga Valeriano,
Carlos Eduardo Pereira Corbett,
Marcia Dalastra Laurenti Tags: ORIGINAL ARTICLE Source Type: research
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