Mass spectrometry based translational neuroinjury proteomics

Publication date: 2013 Source:Translational Proteomics, Volume 1, Issue 1 Author(s): Ahmed Moghieb , Manasi Mangaonkar , Kevin K.W. Wang Neuroinjury, including traumatic brain injury, ischemic and hemorrhagic stroke (intracerebral hemorrhage), subarachnoid hemorrhage and spinal cord injury, collectively is a significant biomedical problem worldwide. Yet there are few therapeutic options available. We submit that mass spectrometry-based proteomic approach can have a potentially high impact in biomarkers discovery and drug target identification for various forms of CNS injury. This review provides an outline of the most important mass spectrometry-based proteomic application tools (differential, quantitative, and imaging mass spectrometry analysis) being used for translational neuroinjury research from animal studies to clinical studies and validations. Graphical abstract
Source: Translational Proteomics - Category: Biomedical Science Source Type: research