Harnessing autophagy to overcome mitogen ‐activated protein kinase kinase inhibitor‐induced resistance in metastatic melanoma

ConclusionsThese results highlight a novel mechanism of MEKi ‐induced drug resistance and suggest that targeting autophagy may be a translatable approach to resensitize drug‐resistant melanoma cells to the cytotoxic effects of MEKi.

Source: British Journal of Dermatology - November 25, 2018 Category: Dermatology Authors: S. Verykiou, M. Alexander, N. Edwards, R. Plummer, B. Chaudhry, P.E. Lovat, D.S. Hill Tags: Translational Research Source Type: research