Neuropeptide Y receptor interactions regulate its mitogenic activity

Neuropeptide Y (NPY) is a multifunctional neurotransmitter acting via G protein-coupled receptors - Y1R, Y2R and Y5R. NPY activities, such as its proliferative effects, are mediated by multiple receptors, which have the ability to dimerize. However, the role of this receptor interplay in NPY functions remains unclear. The goal of the current study was to identify NPY receptor interactions, focusing on the ligand-binding fraction, and determine their impact on the mitogenic activity of the peptide.

Source: Neuropeptides - November 26, 2018 Category: Neuroscience Authors: Magdalena Czarnecka, Congyi Lu, Jennifer Pons, Induja Maheswaran, Pawel Ciborowski, Lihua Zhang, Amrita Cheema, Joanna Kitlinska Source Type: research