Antiinflammatory and antioxidant activities of a polyphenol ‐rich extract from Zizyphus lotus L fruit pulp play a protective role against obesity

AbstractZizyphus lotus (Zl) is used widely as a source of food and for the treatment of various ailments. Therefore, we investigated the biological activities ofZl against obesity and related disorders. Hence, maleWistar rats received either control diet, high fat diet (HFAD), or HFAD supplemented with theZl pulp (HFADP) for 14  weeks. RAW 264.7 cells were used for the determination of antiinflammatory activities in vitro. It was observed that HFDP resulted in significantly reduced weight, blood sugar, and oxidative stress than HFAD. In addition,Zl extract co ‐treatment with LPS reduced the mRNA expression of MCP‐1, pro‐inflammatory cytokines (IL‐6, TNF‐α), and increased the level of IL‐10, an antiinflammatory cytokine, in LPS‐stimulated RAW 264.7 cells. Moreover, nitric oxide synthesis and the expression of iNOS were decreased byZl extract in RAW 264.7 cells.Zl extract also possessed a significant antioxidant capacity and ferric ‐reducing power. Our results validate the traditional use ofZl.Practical applicationZizyphus lotus is commonly used as food in different countries and is easily available. Scientific validation of the traditional use of plants can be significant in the prevention and treatment of different disorders. Naturally occurring products are generally safe to use, have fewer side effects, and can be self ‐administered. Hence, specialized health‐care supervision is not necessary. Our study supports the traditional use ofZizyphus lotus to ...
Source: Journal of Food Biochemistry - Category: Food Science Authors: Tags: FULL ARTICLE Source Type: research