Antioxidant and hepatoprotective potential of Plantago major growing in Egypt and its major phenylethanoid glycoside, acteoside

AbstractThe defatted aqueous methanolic extract of the air ‐dried aerial parts ofPlantago major, collected from Nile delta, Egypt, was evaluated for its antioxidant and hepatoprotective effects. The major phenolic constituent; acteoside was isolated. Meanwhile,P. major exhibited potent hepatoprotective effect as it inhibited the serum activity elevation of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and gamma ‐glutamyl transferase (GGT) enzymes and total and direct bilirubin. It increased the serum total protein and albumin and attenuated CCl4‐induced lipid peroxidation (LPO) and increased GSH in the liver homogenates. Liver histopathology supported the biochemical findings. Acteoside inhibited lipopolysaccharide induced production of nitric oxide in RAW264.7 macrophages (IC50, 75.0 μM) and scavenged both superoxide radical (IC50, 1.51 μM) and DPPH radical (IC50 of 11.27 µM).P. major showed significant DPPH scavenging activity in vitro (IC50, 7.32 μg/mL). It could be concluded that,P. major has potent antioxidant, anti ‐inflammatory, and hepatoprotective activities.Practical applicationsPlantago major L. is an edible plant that is used as food, particularly at the end of spring, just before the harvest of common vegetables. The plant grows wildly at canal banks of the Nile delta in Egypt and represents a very cheap food for farmers when frequent vegetables are not available. The research showed that the defatted aq...
Source: Journal of Food Biochemistry - Category: Food Science Authors: Tags: FULL ARTICLE Source Type: research