Resveratrol attenuates Nitrosodiethylamine ‐induced liver injury in anti‐inflammatory manner via regulating cyclooxygenase‐2

This study reveals that Resveratrol offers hepatoprotection against NDEA‐induced injury through its anti‐inflammatory action and declining COX‐2 expression.Practical applicationsDespite various documented roles of Resveratrol, there is still a paucity of literature supporting its hepatoprotective role. The growing prevalence of liver diseases has witnessed a surge of interest in medicinally important botanicals wherein hepatoprotective active ingredients can be identified. Although herbal medication is preferred over synthetic pharmaceuticals because of their inherent efficacy and negligible side ‐effects, identification and mode of action of active ingredients requires compatible attention. This study is the first that reveals anti‐inflammatory potential of Resveratrol, exerted via declining COX‐2 that offers hepatoprotection against NDEA‐induced liver fibrosis. These findings sugge st Resveratrol as a potential anti‐fibrotic agent and the COX‐2 as a prospective target for drug discovery.

Source: Journal of Food Biochemistry - October 24, 2018 Category: Food Science Authors: Devoshree Mukherjee, Riaz Ahmad Tags: FULL ARTICLE Source Type: research