Chemical components and bioactivity evaluation of extracts from pear (Pyrus Ussuriensis Maxim) fruit

AbstractIn order to discover the bioactive metabolites ofPyrus ussuriensis Maxim, the systematic chemical and pharmacological investigations were performed. The ethyl acetate extract of the plant displayed activities against ear edema in mice, with an inhibition rate of 17.1%, at a dose of 400mg/kg in vivo. Meanwhile, the ethyl acetate extract showed the best apophlegmatic (inhibition: 49.9%) and antitussive effects (inhibition: 34%) at 800mg/kg in vivo tests, and inhibition of NO production (IC50=0.06 μg/mL). Subsequently, twelve compounds were isolated from the ethyl acetate extract and identified as friedelin (1), daucosterol (2), β‐sitosterol (3), betulinic acid (4), oleanolic acid (5), ursolic acid (6), 2 ‐O‐buty‐1‐O’‐(2‐ethylhexyl) benzene‐1,8‐dicarboxylate (7), Narcissin (8), 3 ‐hydroxy‐3‐carboxyl‐glutaric acid dimethyl ester (9), 2 ‐hydroxyl ‐butanediol icacid‐4‐methyleste (10), myristic acid (11), and (Z) ‐11‐hexadecen‐1‐ol acetate (12). Among them, compounds1,2,4,5,6, and11 exhibited moderate indirect inhibitory effects on lipopolysaccharide ‐induced NO and TNF‐α production.Practical applicationsPyrus ussuriensis Maxim is an edible and medical fruit with many functional properties. Unfortunately, few literatures about bioactive components of this fruit have been investigated. The result indicated thatP. ussuriensis have obvious anti ‐inflammatory, antitussive, and apophlegmatic activities, which were associated wi...
Source: Journal of Food Biochemistry - Category: Food Science Authors: Tags: FULL ARTICLE Source Type: research