How do methanol and higher alcohols found in alcoholic beverages affect membrane fluidity and migration of granulocytes?

We examined the effects of OAAs alone and in combination with ethan ol on these processes. Granulocytes isolated from human blood were treated separately with methanol, ethanol, and a mixture of OAAs including methanol, 1‐propanol, 2‐propanol, 1‐butanol, 2‐butanol, isobutanol, and isoamyl alcohol at biologically relevant concentrations. The membrane fluidity and migration activity of granulocytes was examined by fluorescence anisotropy method and migration chambers, respectively. Our findings showed that OAAs increased membrane fluidity and migration activity of granulocytes in a concentration‐dependent manner and when combined with ethanol they caus ed a further increase in the migration activity of granulocytes. It is possible that OAAs consumed with alcoholic beverages may further enhance migration of granulocytes in heavy drinkers and contribute to ethanol‐induced liver damage.Practical applicationsThe consumption of OAAs in alcoholic beverages has been hypothesized as an additional risk factor for the development of alcoholic liver diseases. To confirm this suggestion, the potentially adverse effects of exposure to OAAs should be further examined. Our investigation provides new toxicological data on the effects of OAAs found in alcoholic beverages. The results of this study can be used for more precise toxicological evaluations to clarify whether OAAs may pose an additional risk factor for the development of alcoholic liver diseases. Furthermore, information ...
Source: Journal of Food Biochemistry - Category: Food Science Authors: Tags: FULL ARTICLE Source Type: research