Mentha longifolia alleviates experimentally induced angina via decreasing cardiac load

AbstractAngina occurs due to imbalance between heart oxygen demand and supply and is associated with serious morbidity and mortality. Here, the possible antianginal effect ofMentha longifolia extract was studied in experimental model of angina. Aerial parts ofM. longifolia were extracted, standardized, and given to rats three days before angina. Heart hemodynamics and conductivity were recorded by microtip catheter and surface electrodes.M. longifolia extract significantly alleviated the sustained decline in cardiac contractility after vasopressin exposure. However,M. longifolia did not affect the impaired cardiac dilation after vasopressin. Heart rate was significantly decreased after vasopressin exposure in rats treated withM. longifolia compared with untreated animals. In addition,M. longifolia produced more increase in systolic and diastolic durations after vasopressin exposure compared with untreated animals. Moreover, the plant extract alleviated the ST height changes during vasopressin injection.M. longifolia extract alleviates impaired cardiac function associated with angina through decreasing heart work.Practical applicationsThe present study is the first to study the effect ofM. longifolia in an experimental model of angina.M. longifolia alleviated the impaired cardiac contractility associated with angina exposure. The antianginal effect ofM. longifolia could be through reducing cardiac load. This can be concluded from the decrease in heart rate and the systolic and...

Source: Journal of Food Biochemistry - October 29, 2018 Category: Food Science Authors: Ahmad S. Azhar, Hany M. El ‐Bassossy, Hossam M. Abdallah Tags: SHORT COMMUNICATION Source Type: research