Effective angiogenesis requires regulation of phosphoinositide signaling

Publication date: Available online 26 November 2018Source: Advances in Biological RegulationAuthor(s): Elizabeth Michele Davies, Rajendra Gurung, Kai Qin Le, Christina Anne MitchellAbstractPhosphoinositide signaling regulates numerous downstream effectors that mediate cellular processes which influence cell cycle progression, migration, proliferation, growth, survival, metabolism and vesicular trafficking. A prominent role for phosphoinositide 3-kinase, which generates phosphatidylinositol 3,4,5-trisphosphate, a phospholipid that activates a plethora of effectors including AKT and FOXO during embryonic and postnatal angiogenesis, has been described. In addition, phosphatidylinositol 3-phosphate signaling is required for endosomal trafficking, which contributes to vascular remodeling. This review will examine the role phosphoinositide signaling plays in the endothelium and its contribution to sprouting angiogenesis.

Source: Advances in Biological Regulation - November 26, 2018 Category: Biology Source Type: research