What ’s in a name? Molecular sub‐classification of sarcomas creates fresh challenges

AbstractThis commentary addresses the issue of the classification of sarcomas in the article written by Watson and colleagues published recently in this journal. That article delves into the molecular characterization and distinct phenotypes of some recently described entities (e.g. BCOR ‐rearranged sarcomas, CIC‐fused sarcomas), and describes new groups with common characteristics. This commentary focuses on several questions raised in the article, such as what makes a group of sarcomas become a clinical entity, which should be the main driver of sarcoma classification, how the classification of small round cell sarcomas is expected to evolve and how high‐throughput techniques could be applied to sarcoma diagnosis in the short term.

Source: The Journal of Pathology - November 25, 2018 Category: Pathology Authors: Juan D íaz‐Martín, Michele Biscuola, Jonathan Benoit, David Marcilla, Gema Civantos, Enrique de Álava Tags: Invited Commentary Source Type: research