The therapeutic potential of regulatory T lymphocytes in periodontitis: A systematic review

This systematic review aimed to: (a) generate a descriptive synthesis of preclinical studies assessing the therapeutic potential of regulatory T lymphocytes (Tregs) to arrest periodontitis, (b) evaluate the methodological heterogeneity of the reviewed animal studies and (c) assess the risk of bias (RoB) of the included studies. The electronic search for animal studies included the MEDLINE, EMBASE, Web of Science and LILACS databases. In addition, a manual search assessed the high ‐ranked scientific journals in “periodontics/immunology” and the references listed in the included studies. There were no language, year or publication status restrictions. Two independent reviewers selected and extracted the data, and Cohen's Kappa coefficient was calculated to determine the inter‐examiner agreement. The Systematic Review Center for Laboratory Animal Experimentation's (SYRCLE) tool was used to assess the RoB. A total of 21 of the 425 studies obtained from the database search were included. Treg function was mainly described inPorphyromonas gingivalis‐induced periodontitis (57.1%) in mice (76.2%), where Treg suppression was strongly related to disease progression and Treg induction was strongly related to immuno‐inflammatory response reduction. Of those 21 studies, eight included eight animal experiments using three distinct therapeutic appr oaches, including:P.  gingivalis‐driven immunization (n = 3), retinoic acid inoculation (n = 2) and anti‐inflammatory molec...
Source: Journal of Periodontal Research - Category: Dentistry Authors: Tags: REVIEW ARTICLE Source Type: research