Synthesis and characterization of superparamagnetic nanohybrid Fe3O4/NH2 ‐Ag as an effective carrier for the delivery of acyclovir

Superparamagnetic Fe3O4/NH2‐Ag has been found as an effective carrier for the controlled loading and release of acyclovir at pH 7.4. In this work, superparamagnetic nanohybrid material Fe3O4/NH2‐Ag is uncovered as an attractive magnetic carrier for the controlled delivery of acyclovir (ACV). This magnetic nanoparticle was synthesized using the hydrothermal method. Then, the surface hydroxyl groups were extended by treating with tetraethyl orthosilicate (TEOS) and (3‐aminopropyl) trimet hoxysilane (APTMS). Finally, Ag nanoparticles were created on the surface of Fe3O4@SiO2‐NH2 nanospheres via reduction of Ag+ ions. Decorated hybrid magnetite nanoparticles were then loaded with ACV as an active antiviral drug model. For this purpose, the amount of loading/release of the drug was investigated at different pH values. Structural characteristics of the functionalized nanomagnetic materials were investigated by Fourier transform ‐infrared spectroscopy, transmission electron microscopy, X‐ray diffraction, thermogravimetric analysis and vibrating‐sample magnetometry. The findings indicated that Fe3O4/NH2‐Ag is highly efficient in loading and release of the selected model drug at pH 7.4.
Source: Applied Organometallic Chemistry - Category: Chemistry Authors: Tags: FULL PAPER Source Type: research