Biological evaluation of a novel amino acid ‐based macrocyclic Mn(III) and Fe(III) complexes

Metal complexes derived from curcumin based non ‐enolisable diketone and L‐Phenylalanine has been synthesized and the interaction of these metal complexes with CT‐DNA and BSA is studied using spectrocopic tools and computational docking studies. The complexes are found to bind with CT‐DNA via intercalation. The intrinsic flourescence of B SA is quenched by the complexes as a result of static quenching. It is found that the complexes act as a novel drug targets. A new tetradentate ligand 4 ‐benzylidine‐1,7‐bis(4‐hydroxy‐3‐methoxyphenyl)hepta‐1,6‐diene‐3,5‐bis(2‐imino‐3‐phenylpropanoic acid) of the type N2O2 has been synthesized from curcumin derived non ‐enolisable diketone and L‐phenylalanine and complexed with Mn(III) and Fe(III) metal ions. The non‐enolisable curcumin was obtained by Knoevenagel condensation. The synthesized ligand and complexes (MnL& FeL) were characterized by various spectral techniques. Using absorption and emission spectral techniques CT ‐DNA and BSA binding studies has been carried out. The absorption and emission spectral tools reveal the intercalative mode of binding between the CT‐DNA and the metal complexes. The fluorescence of BSA was quenched around 340 nm by the metal complexes followed by static quenching mechanism. Th e emission spectra of BSA were recorded at three different temperatures. The binding sites, mode of binding, binding energy and the donor‐acceptor distance on the basis of Forster's ...
Source: Applied Organometallic Chemistry - Category: Chemistry Authors: Tags: FULL PAPER Source Type: research