Green Synthesis of new Trizole Based Heterocyclic Amino Acids Ligands and their Transition Metal Complexes. Characterization, Kinetics, Antimicrobial and Docking Studies

Two novel amino acids imine ligands (H2L1 and H2L2) have been synthesized using green condensation reaction from 2 ‐[3‐Amino‐5‐(2‐hydroxy‐phenyl)‐5‐methyl‐1,5‐dihydro‐[1,2,4]triazol‐4‐yl]‐3‐(1H‐indol‐3‐yl)‐propionic acid with benzaldehyde / p‐flouro benzaldehyde (1:1 molar ratio) in the presence of lemon juice as a natural acidic catalyst in aqueous medium. Two novel amino acids imine ligands (H2L1 and H2L2) have been synthesized using green condensation reaction from 2 ‐[3‐Amino‐5‐(2‐hydroxy‐phenyl)‐5‐methyl‐1,5‐dihydro‐[1, 2, 4]triazol‐4‐yl]‐3‐(1H‐indol‐3‐yl)‐propionic acid with benzaldehyde/p‐flouro benzaldehyde (1:1 molar ratio) in the presence of lemon juice as a natural acidic catalyst in aqueous medium. Their transition metal complexes have been prepared in a molar ratio (1:1). Characterization of the ligands and complexes using elemental analysis, spectroscopic studies,1HNMR,13CNMR, and thermal analysis has been reported. E*, ΔH*, ΔS* and ΔG* thermodynamic parameters, were calculated to throw more light on the nature of changes accompanying the thermal decomposition process of these complexes. The molar conductance measurement of metal complexes showed nonelectrolyte behavior. The metal complexes of the two ligands ha ve tetrahedral geometry with a general molecular structure [M(H2L)Xn], where [(M  = Mn (II), Co (II), Cu (II) and Zn (II), X = Cl,n = 2]; M = VO (II), X = SO4,n�...

Source: Applied Organometallic Chemistry - November 7, 2018 Category: Chemistry Authors: A.M. El ‐Saghier, H.F. Abd El‐Halim, Laila H. Abdel‐Rahman, A. Kadry Tags: FULL PAPER Source Type: research