A new nano ‐sized mononuclear Cu (II) complex with N,N‐donor Schiff base ligands: sonochemical synthesis, characterization, molecular modeling and biological activity

A new copper (II) Schiff base complex has been synthesized by reflux and sonochemical methods and was confirmed by different spectroscopic techniques. The complexes (bulk and nano) have been screened for their in vitro microbiology activity against four types of bacteria and three strains of fungi. Finally, the copper complex was optimized at the DFT ‐B3LYP/6–31 + G(d) calculation level using the Gaussian 03 package. A new, simple Cu2+ nano ‐structure Schiff base complex in methanol medium has been synthesized by the ultrasonic method. Structure of the compound was confirmed by FT‐IR, GC‐Mass and other spectroscopic techniques. The copper oxide (CuO) was achieved from the copper nano‐structure Schiff base complex as the raw mat erial after calcination for 3 hr at 600 °C. According to results Cu2+ gives a complex with mole ratio 1:2 of metal to ligand (ML2) with Schiff base which a distorted square planer is the most probable geometry for it. The calculations results from XRD patterns propose the nano ‐sized complexes. The SEM images show morphology of both the copper complex and the CuO powder were plate‐like. The metal chelates of Cu2+ in two states of bulk and nano have been screened for their in vitro antibacterial activity against four bacteria, gram ‐positive (Staphylococcus aureus) and gram ‐negative (Escherichia coli) and three strains of fungus (Aspergillus flavus). The nano metal chelates were shown to possess more antibacterial activity than...
Source: Applied Organometallic Chemistry - Category: Chemistry Authors: Tags: FULL PAPER Source Type: research