The antioxidant flavonoid monoHER provides efficient protection and induces the innate Nrf2 mediated adaptation in endothelial cells subjected to oxidative stress

In this study the effect of monoHER on the oxidative stress as well as the adaptive response was investigated. It was found that monoHER protected against oxidative stress caused in HUVECs by H2O2, while monoHER did not prevent the induction of the adaptive response, including the nuclear translocation of Nrf2 as well as the upregulation of HO-1 gene expression. Remarkably, monoHER added to HUVECs which were not subjected to oxidative stress did not cause an adaptive response. The concept that emerges is that by scavenging ROS, the oxidized monoHER formed channels the reactivity selectively to thiol groups. Oxidized monoHER adducts Keap1, which can set the innate Nrf2 machinery into motion and enforce the endogenous antioxidant defense. In this way monoHER acts as a double-edged sword in cells subjected to oxidative stress; the antioxidant offers direct protection and induces adaptation. Graphical abstract

Source: PharmaNutrition - October 12, 2014 Category: Nutrition Source Type: research