MALDI –MSI Pilot Study Highlights Glomerular Deposits of Macrophage Migration Inhibitory Factor as a Possible Indicator of Response to Therapy in Membranous Nephropathy

Conclusions and clinical relevanceDespite much effort being made in recent years to understand the pathogenesis of MN, a biomarker able to predict the outcome of these patients following therapeutic treatment is still lacking. Here, a protein (MIF), verified by immunohistochemistry, that can differentiate between these MN patients and could be a valuable starting point for a further study focused on verifying its predictive role in therapy response is highlighted.

Source: Proteomics. Clinical Applications - November 22, 2018 Category: Biochemistry Authors: Vincenzo L'Imperio, Andrew Smith, Elena Ajello, Isabella Piga, Martina Stella, Vanna Denti, Silvia Tettamanti, Renato Alberto Sinico, Federico Pieruzzi, Maurizio Garozzo, Gisella Vischini, Manuela Nebuloni, Fabio Pagni, Fulvio Magni Tags: Research Article Source Type: research