Italian validation of the functional difficulties questionnaire (FDQ ‐9) and its correlation with major determinants of quality of life in adults with hypermobile Ehlers–Danlos syndrome/hypermobility spectrum disorder

The 2017 nosology defines the new criteria for hypermobile Ehlers –Danlos syndrome (hEDS), which is now considered one end of a continuous spectrum encompassing isolated, nonsyndromic joint hypermobility (JH) and hypermobility spectrum disorders (HSDs). Preliminary data indicate a link between JH and neurodevelopmental disorders and, in particular, developmental coordination disorder (DCD) in children. Assessing DCD in adults is difficult and the recently described functional difficulties questionnaire 9 (FDQ‐9) is one of the few available tools. The aims of this study are to (a) validate FDQ‐9 written in Italian and present normal values in 230 Italia n controls; (b) explore the relationship of FDQ‐9 with the brief pain inventory, composite autonomic symptom score 31, multidimensional fatigue inventory, attention deficit/hyperactivity disorder self‐report version 1.1, and the SF‐36 for quality of life in 105 Italian adults with hEDS/HSD. Va lidation of the FDQ‐9 in Italian was carried out by translation, cross‐cultural adaptation and test/retest reliability analysis. A case–control study was performed comparing the FDQ‐9 outcome between 105 patients and 105 sex‐ and age‐matched controls. Fifty‐nine percent of the patients resulted positive compared to the 3.8% of controls (p value< .00001). In patients, FDQ ‐9 positive result associated with positive attention deficit/hyperactivity disorder self‐report version 1.1 (OR = 4.04). Multivariate ...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - Category: Genetics & Stem Cells Authors: Tags: RESEARCH ARTICLE Source Type: research