Macrophage CD40 ‐signaling drives experimental autoimmune encephalomyelitis

In conclusion, the CD40 ‐TRAF6 signaling pathway in MHCII+ cells plays a key role in neuro ‐inflammation and demyelination during EAE. Concomitant with the fact that CD40‐TRAF6 interactions are predominant in macrophages, depletion of myeloid CD40 also reduces neuro‐inflammation. CD40‐TRAF6 interactions thus represent a promising therapeutic target for multiple sclerosis.

Source: The Journal of Pathology - November 24, 2018 Category: Pathology Authors: Suzanne A.B.M. Aarts, Tom T.P. Seijkens, Pascal J.H. Kusters, Claudia M. Tiel, Myrthe E. Reiche, Myrthe Toom, Linda Beckers, Cindy P.A.A. Roomen, Menno P.J. Winther, Gijs Kooij, Esther Lutgens Tags: Original Paper Source Type: research