Fibrous dysplasia of the jaws: Integrating molecular pathogenesis with clinical, radiological, and histopathological features

Fibrous dysplasia is a non ‐neoplastic developmental process that affects the craniofacial bones, characterized by painless enlargement as a result of bone substitution by abnormal fibrous tissue. Postzygotic somatic activating mutations in theGNAS1 gene cause fibrous dysplasia and have been extensively investigated, as well as being helpful in the differential diagnosis of the disease. Fibrous dysplasia may involve one (monostotic) or multiple bones (polyostotic), sporadically or in association with McCune ‐Albright syndrome, Jeffe‐Lichenstein syndrome, or Mazabreud syndrome. This review summarizes the current knowledge on fibrous dysplasia, emphasizing the value of integrating the understanding of its molecular pathogenesis with the clinical, radiological, and histopathological features. In addit ion, we address important aspects related to the differential diagnosis and patient management.

Source: Journal of Oral Pathology and Medicine - November 20, 2018 Category: Pathology Authors: Tha ís dos Santos Fontes Pereira, Carolina Cavalieri Gomes, Peter A Brennan, Felipe Paiva Fonseca, Ricardo Santiago Gomez Tags: INVITED REVIEW Source Type: research