Alterations of the gut microbiome and plasma proteome in Chinese patients with adolescent idiopathic scoliosis

The etiology of adolescent idiopathic scoliosis (AIS), the most common rotational deformity of the spine, is still unclear. Emerging evidence suggests that gut microbiota dysbiosis influences musculoskeletal diseases such as arthritis and osteoporosis. However, the alterations of the fecal microbiome in AIS remain unknown. Thus, the current study was conducted to explore the gut microbiota compositions of Chinese AIS patients. Microbiota communities in the feces of 51 AIS patients and 34 age- and sex-matched healthy individuals were investigated using 16S rRNA sequencing.

Source: Bone - November 24, 2018 Category: Orthopaedics Authors: Nan Shen, Nan Chen, Xuan Zhou, Bing Zhao, Renxiu Huang, Juping Liang, Xiaoyan Yang, Meijia Chen, Yuanyuan Song, Qing Du Tags: Full Length Article Source Type: research