Prevalence and determinants of resistance mutations in HIV ‐1‐infected patients exposed to integrase inhibitors in a large Italian cohort

ConclusionsThe results support integrase resistance testing in INSTI ‐experienced patients. Emergence of INSTI resistance is facilitated by the reduced genetic barrier of the regimen as a consequence of resistance to companion drugs. However, INSTI resistance may become undetectable by standard population sequencing upon INSTI discontinuation.

Source: HIV Medicine - November 21, 2018 Category: Infectious Diseases Authors: S Modica, B Rossetti, F Lombardi, F Lagi, M Maffeo, R D'Autilia, M Pecorari, I Vicenti, B Bruzzone, G Magnani, S Paolucci, D Francisci, G Penco, D Sacchini, M Zazzi, A De Luca, A Di Biagio Tags: Original Research Source Type: research