Dimeric Fc γR ectodomains detect pathogenic anti‐platelet factor 4–heparin antibodies in heparin‐induced thromobocytopenia

ConclusionsThis study found the cell ‐free, function‐based dimeric rsFcγRIIa assay to be convenient, simple, and potentially predictive of HIT. The assay had improved specificity over the IgG ELISA, and correlated strongly with the AcuStar HIT IgG‐specific assay, warranting further evaluation of its potential to identify HIT in larger patient cohorts.

Source: Journal of Thrombosis and Haemostasis - November 20, 2018 Category: Hematology Authors: B. D. Wines, C. W. Tan, E. Duncan, S. McRae, R. I. Baker, R. K. Andrews, S. Esparon, E. E. Gardiner, P. M. Hogarth Tags: Brief Report Source Type: research