Extracellular matrix remodeling effects of serum amyloid A1 in the human amnion: implications for fetal membrane rupture

ConclusionsThese data highlight a possible role for SAA1 in ECM remodeling preceding membrane rupture by regulating the expression of collagenases MMP ‐1, ‐8, ‐13 and LOXL1 through TLR4‐mediated activation of the NFκB and MAPK pathways in amnion fibroblasts.This article is protected by copyright. All rights reserved.

Source: American Journal of Reproductive Immunology - November 21, 2018 Category: Allergy & Immunology Authors: Ya ‐wei Wang, Wang‐sheng Wang, Lu‐yao Wang, Yi‐Rong Bao, Jiang‐wen Lu, Yi Lu, Chu‐yue Zhang, Wen‐jiao Li, Kang Sun, Hao Ying Tags: Original Article Source Type: research