Aptamer ‐targeted DNA nanostructures with doxorubicin to treat protein tyrosine kinase 7‐positive tumours

ConclusionsIn this work, we successfully constructed a PTK7 ‐targeting aptamer‐guided DNA tetrahedral nanostructure (s‐TDN) as a drug delivery system via a facile one‐pot synthesis method. The results showed that s‐TDN:DOX exhibited enhanced cytotoxicity against PTK7‐positive CCRF‐CEM cells, with a minor effect against PTK7‐negative Ramos cel ls. Hence, this functionalized TDNs drug delivery system displayed its potential application in targeting PTK7‐positive tumour T‐cell acute lymphoblastic leukaemia.

Source: Cell Proliferation - October 12, 2018 Category: Cytology Authors: Mengting Liu, Wenjuan Ma, Qianshun Li, Dan Zhao, Xiaoru Shao, Qian Huang, Liying Hao, Yunfeng Lin Tags: ORIGINAL ARTICLE Source Type: research