Recent progress in the emerging role of exosome in hepatocellular carcinoma
AbstractExosomes are small membrane vesicles 50 ‐150 nm in diameter released by a variety of cells, which contain miRNAs, mRNAs and proteins with the potential to regulate signalling pathways in recipient cells. Exosomes deliver nucleic acids and proteins to participate in orchestrating cell‐cell communication and microenvironment modulation . In this review, we summarize recent progress in our understanding of the role of exosomes in hepatocellular carcinoma (HCC). This review focuses on recent studies on HCC exosomes, considering biogenesis, cargo and their effects on the development and progression of HCC, including chemoresistance, epithelial‐mesenchymal transition, angiogenesis, metastasis and immune response. Finally, we discuss the clinical application of exosomes as a therapeutic agent for HCC.
Source: Cell Proliferation - Category: Cytology Authors: Mubalake Abudoureyimu,
Hao Zhou,
Yingru Zhi,
Ting Wang,
Bing Feng,
Rui Wang,
Xiaoyuan Chu Tags: REVIEW ARTICLE Source Type: research
More News: Cancer & Oncology | Carcinoma | Cytology | Hepatocellular Carcinoma | Liver Cancer | Study